Temperature-Dependent Effects of Induced Hyperthermia, Including Whole-Body Hyperthermia, on the Hallmarks of Cancer: A Systematic Review.

ABSTRACT: Background/Objectives: Cancer's complexity can be rationalized through the "hallmarks of cancer," which define the key biological capabilities driving malignancy. Induced hyperthermia-an adjunctive therapy that elevates body temperature above the normal setpoint for a defined period-has been explored for its modulatory effects on these hallmarks. This systematic review aims to evaluate the effects and mechanisms of induced hyperthermia on tumor cells through the established hallmarks of cancer framework. Methods: A systematic search following the Cochrane guidelines and PRISMA assessment tool was conducted in PubMed and Cochrane Library (2000-2025) to identify reviews on the effects of induced hyperthermia on cancer hallmarks. Studies' predefined inclusion criteria were indep

SUBMITTER: Gorbaslieva I 

PROVIDER: S-EPMC12691179 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature