Effects of Imposed Defocus on Inhibitor of DNA-Binding Gene Expression in Chick Posterior Ocular Tissues.

ABSTRACT: Inhibitors of DNA-binding genes (Ids) are key downstream targets of bone morphogenetic proteins (BMPs), gene expression of which is differentially regulated in the chick retinal pigment epithelium (RPE) during altered eye growth. The current study examined the effects of optical defocus on the gene expression of Id1-4 in chick retina, RPE, and choroid after 2 or 48 h of monocular +10 or -10 D lens wear. Defocus-induced differential Id gene expression was observed in all three tissues, with defocus sign and treatment duration-related differences. In the choroid, 2 h of +10 D (myopic) defocus induced upregulation of all four of the Ids, with this effect also seen with 48 h exposure, for both Id3 and Id4 genes. Two hours of +10 D defocus also induced

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12691209 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature