Gut Microbiota Signatures Associate with Chemotherapy-Related Adverse Events in Breast Cancer Patients.

ABSTRACT: Background/Objectives: Chemotherapy-induced adverse events significantly impact cancer treatment outcomes and patient quality of life. Emerging evidence suggests that gut microbiota composition may influence individual susceptibility to chemotherapy toxicity. This study investigated associations between gut microbiome alterations and specific chemotherapy-related adverse events in breast cancer patients undergoing cancer treatment. Methods: We conducted a prospective cohort study of 81 breast cancer patients receiving chemotherapy between May 2018 and October 2022. Gut microbiome composition was analyzed using 16S rRNA sequencing across multiple taxonomic levels. Alpha diversity (Chao1 estimator) and beta diversity (PERMANOVA) analyses were performed to assess microbial richn

SUBMITTER: Hsu JW 

PROVIDER: S-EPMC12691247 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature