The Impact of <i>MEI1</i> Alternative Splicing Events on Spermatogenesis in Mongolian Horses.

ABSTRACT:

Background

Normal spermatogenesis in Mongolian horses depends on the mitotic division of spermatogonia, two successive meiotic divisions, and the morphological transformation of spermatids into mature spermatozoa. The MEI1 gene is involved in the meiosis cycle and is required for normal chromosome association during meiosis. Previous studies have shown that alternative splicing of MEI1 may promote spermatogenesis in Mongolian horses. In this paper, the regulatory effects of different MEI1 alternative splicing events on Mongolian horse spermatogenesis are investigated.

Results

In this study, two overexpressed lentiviral vectors with mutually exclusive exon (MXE) and skipped exon (SE) events of MEI1 were constructed and successfully used to infect S

SUBMITTER: Song D 

PROVIDER: S-EPMC12691261 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature