Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.

ABSTRACT: Thermogenic adipocytes present a promising therapeutic strategy for metabolic diseases. While murine models have provided valuable insights into thermogenic adipose tissue, their relevance to human physiology is constrained by species-specific differences in tissue distribution and thermogenic capacity. In vitro human models offer a more controlled platform to study adipocyte differentiation, addressing challenges such as limited access to deep fat depots and individual variability. This systematic review summarizes the current literature on human in vitro models for thermogenic adipocyte induction, encompassing 117 studies involving primary human adipocyte progenitors differentiated into thermogenic adipocytes in 2D cultures. Most studies relied on classical adipogenic inducers, including

SUBMITTER: Anatildes da Silva de Paula GL 

PROVIDER: S-EPMC12691314 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature