Targeting Cancer with Redox Catalysis: Manganese Porphyrins and Ascorbate Synergistically Induce Selective Oxidative Stress and Necrotic Cell Death.

ABSTRACT:

Background

The combination of manganese porphyrins (MnPs) and ascorbate (ASC) represents a promising redox-based therapeutic approach for selectively targeting cancer cells. We investigated the cytotoxic effects of two structurally distinct MnPs (MnTPPS and MnF₂BMet) with differing lipophilicity and potential membrane permeability in combination with ASC.

Methods

Cancer cell lines (MCF-7, PANC-1, U87, T98G, AT-2) and normal human dermal fibroblasts (HDFs) were treated with MnTPPS and MnF₂BMet in the absence or presence of ASC. Viability, migration potential, and intracellular oxidative stress were assessed using single-cell methods.

Results

MnPs alone exhibited no intrinsic cytostatic or cytotoxic activity, as confirmed by proliferation, viabilit

SUBMITTER: Rapala M 

PROVIDER: S-EPMC12691324 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature