Pulmonary Embolism and ABO Blood Type: A Systematic Review.

ABSTRACT: Background: Pulmonary embolism (PE) remains a major cause of cardiovascular morbidity and mortality. Classical risk factors explain only part of the interindividual variability in thrombotic risk. Non-O blood groups are associated with higher plasma levels of von Willebrand factor and factor VIII, suggesting a potential prothrombotic mechanism. This systematic review and limited meta-analysis examined the relationship between ABO blood group and PE risk. Methods: Following PRISMA 2020 guidelines, PubMed, Embase, and Web of Science were searched through August 2025 for observational studies reporting ABO blood group and objectively confirmed PE in adults. Eligible designs included cohort, case-control, and registry-based studies. Two reviewers independently extracted data and

SUBMITTER: Jamal Eddin A 

PROVIDER: S-EPMC12691326 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature