Metastatic Pheochromocytoma/Paraganglioma: Diagnostic Performance of Functional Imaging (¹⁸F-Fluoro-L-DOPA-, ⁶⁸Ga-DOTA- and ¹⁸F-Fluoro-Deoxyglucose-Based PET/CT) and of ¹²³I-MIBG Scintigraphy in 57 Patients and 527 Controls During Long-Term Follow-Up.

ABSTRACT: Background: Large-scale data on the diagnostic performance of functional imaging in metastatic pheochromocytoma/paraganglioma (PPGL) are scarce. Objective: To analyze the diagnostic accuracy of functional imaging for the assessment of metastases during long-term follow-up (FU). Design: Retrospective cohort study, 1991-2025. Setting: Referral center. Outcomes: Sensitivity and specificity of ¹²³MIBG-, ¹⁸F-DOPA-, ⁶⁸GaDOTA-based and ¹⁸FDG PET/CT. Patients: Patients with metastatic PPGL and without PPGL, ≥1 functional imaging prior to first diagnosis and/or during FU and FU ≥ 3 months. Results: 59 ¹²³MIBG-, 101 ¹⁸F-DOPA-, 11 ¹⁸FDG- and 74 ⁶⁸GaDOTA-based PET/CT

SUBMITTER: Scheuba A 

PROVIDER: S-EPMC12691327 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature