Codify and Localize Lesions on a Coronary Acoustic Map: Scientific Rationale, Trial Design and Artificial Intelligence Algorithm Protocols.

ABSTRACT: In coronary artery disease (CAD), the initiation, progression, and regression of atherosclerosis remain incompletely understood, limiting the effectiveness of specific diagnostic and personalized medicine management strategies based on current imaging and assessment methods. In this scientific rationale and study design analysis, the framework conceptualizes the cardiovascular system as an integrated hydraulic network of pumps and pipes, advancing a shift from static imaging of luminal stenosis toward dynamic assessment of coronary flow. Grounded in fluid mechanics and acoustic principles, this analysis establishes a scientific rationale for an angiographic investigation of hemodynamic disturbances that compromise endothelial integrity in coronary arteries. The first section examines injur

SUBMITTER: Nguyen T 

PROVIDER: S-EPMC12691354 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature