<i>Bacteroides fragilis</i> Promotes Mesenchymal Subtype in Colorectal Cancer.

ABSTRACT: Background/Objectives: Colorectal cancer (CRC) exhibits significant molecular heterogeneity, as reflected in Consensus Molecular Subtype (CMS) classification, and demonstrates extensive crosstalk with the microbiome. However, the role of the microbiome in determining subtypes of CRC, and CMS4 in particular, which represents an aggressive, stromal-rich variant associated with poor prognosis, remains poorly understood. Here, we reveal the role of the tumor microbiome in shaping the tumor microenvironment (TME) and its impact on CMS4 determination. Methods: A total of 25 CRC tissues were analyzed using RNA sequencing and classified with CMScaller to identify significantly enriched microbial species. Functional studies were performed using these CMS-specific microbial species and

SUBMITTER: Chang SY 

PROVIDER: S-EPMC12691386 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature