Inverse Association Between METS-IR and Lung Cancer Risk: The Role of BMI in a Nationwide Korean Cohort.

ABSTRACT:

Background

Although insulin resistance has been implicated in cancer development, its specific role in lung cancer remains unclear. The metabolic score for insulin resistance (METS-IR) is a novel surrogate marker that integrates multiple metabolic parameters and has demonstrated strong predictive value for metabolic disorders. This study aimed to investigate the association between METS-IR and lung cancer incidence in a large-scale nationwide cohort.

Methods

We analyzed data from 322,624 participants of the National Health Insurance Service-National Health Screening Cohort in Republic of Korea. Participants were stratified into METS-IR quartiles, and lung cancer incidence was assessed using Kaplan-Meier survival curves and Cox proportional hazards regression models. Subgroup

SUBMITTER: Shine BK 

PROVIDER: S-EPMC12691392 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature