Suppression of large t antigen-stimulated CD4⁺CD25⁺ and CD8⁺IFN-γ⁺ T cells is strongly associated with low level BK viremia in kidney transplant recipients.

ABSTRACT:

Background

BK polyomavirus (BKPyV) infection following kidney transplantation results from over-suppression of cellular immunity. Currently, there is no established, clinically applicable immunological assay that comprehensively monitors cellular immune responses against BKPyV, incorporating both cytokine production and T cell activation markers. Our study aimed to comprehensively assess both cytokine production and surface activation markers to differentiate kidney transplant recipients (KTR) with low-level (<3,000 copies/mL) BKPyV viremia from those without viremia.

Methods

Thirty-six participants were enrolled, comprising KTR with (BK) and without BKPyV viremia (nBK), alongside healthy controls (HC). Peripheral blood mononuclear cells (PBMC) were stimulated using BKPyV vi

SUBMITTER: Saisorn W 

PROVIDER: S-EPMC12691454 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature