Overexpression of <i>CDC20</i> Confer a Poorer Prognosis in Bladder Cancer Identified by Gene Co-Expression Network Analysis.

ABSTRACT: Background/Objectives: Bladder cancer (BCa) ranks as the tenth most prevalent malignancy worldwide, characterized by high morbidity and mortality rates. Despite advancements in understanding its pathogenesis, the identification of robust prognostic biomarkers remains critical for improving clinical outcomes. This study aims to identify and validate novel prognostic markers for BCa through integrated bioinformatics and experimental approaches. Methods: Gene expression data and clinical information were obtained from the GEO (GSE13507) and TCGA databases. Differential gene expression analysis and weighted gene co-expression network analysis (WGCNA) were employed to identify overlapping genes. Functional enrichment analysis was performed to explore biological functions, followed

SUBMITTER: Yang X 

PROVIDER: S-EPMC12691489 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature