First nationwide survey on <i>Pseudomonas aeruginosa</i> in Bolivia: susceptibility profiles, resistome, and genomic epidemiology.

ABSTRACT: Information on the molecular epidemiology of Pseudomonas aeruginosa and antimicrobial resistance mechanisms is still limited in some South American countries. This study aims to decipher the population structure of 111 extensive drug-resistant P. aeruginosa isolates from a national study conducted in Bolivia during 2023-2024. The antibiotic susceptibility profiles were determined for 15 antipseudomonal agents. All isolates were subjected to whole-genome sequencing (WGS), and, through bioinformatics analysis, sequence types (ST), clonal relatedness, and acquired mutation-driven and transferable resistance mechanisms were elucidated. The most active antipseudomonal agents were colistin (98.2% intermediate, MIC_50/90=1/2 mg/L) and cefiderocol (92.7% susceptible, MIC

SUBMITTER: Alvarado-Orosco N 

PROVIDER: S-EPMC12691617 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature