Clinical emergence of inducible macrolide resistance mediated by acquired <i>erm</i>(41) C28T mutation in <i>Mycobacterium abscessus</i>.

ABSTRACT: Inducible macrolide resistance mediated by the erm(41) T28 allele is a well-established intrinsic mechanism in Mycobacterium abscessus. Here, we report a case of M. abscessus pulmonary disease in which an initial erm(41) C28 isolate developed inducible resistance through a de novo C28T point mutation during prolonged therapy. To our knowledge, this case provides the first clinical evidence that erm(41)-mediated inducible resistance can arise in vivo under antimicrobial selective pressure.

SUBMITTER: He G 

PROVIDER: S-EPMC12691619 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature