Second-generation lysocins as therapeutics for treating <i>Pseudomonas aeruginosa</i> infections.

ABSTRACT: Pseudomonas aeruginosa is a leading cause of nosocomial infections, including pneumonia and urinary tract infections, and the primary cause of morbidity and mortality in cystic fibrosis patients. The emergence of multidrug-resistant strains makes these infections life-threatening. To overcome this challenge, lysocins can be employed as novel antipseudomonals. Lysocins use components of the pyocin antimicrobial system to deliver bacteriophage lysins to their peptidoglycan substrate in Pseudomonas. Peptidoglycan cleavage causes membrane destabilization, cytoplasmic leakage, and disruption of the proton motive force, thereby killing the cell. In our previous proof-of-concept study, the PyS2-GN4 lysocin killed only one-third of P. aeruginosa strains due to the targeted rec

SUBMITTER: Heselpoth RD 

PROVIDER: S-EPMC12691632 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature