<i>Lactobacillus plantarum</i> Lac16 alleviates dextran sodium sulfate-induced colitis in mice by suppressing NLRP3 inflammasome overactivation through microbiota-derived isobutyric acid.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder characterized by immune dysregulation. Therapeutic strategies targeting gut microbiota modulation have been proven to be effective against IBD. This study sought to explore the protective effects of Lactobacillus plantarum Lac16 against dextran sulfate sodium (DSS)-induced colitis and to elucidate its underlying mechanisms. Results illustrated that Lac16 administration significantly ameliorated colitis symptoms, as evidenced by reduced weight loss, attenuated colon shortening, and decreased disease activity index scores. Furthermore, Lac16 treatment restored intestinal barrier integrity, modulated inflammatory cytokine levels, promoted macrophage polarization toward an anti-inflammatory phenotype, and sup

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12691655 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature