IS<i>Aba1</i>-mediated <i>bla</i>_ADC disruption restores third-generation cephalosporin susceptibility in a clinical <i>Acinetobacter baumannii</i> isolate.

ABSTRACT: This study describes the effects of the insertion of ISAba1 in the intrinsic bla_ADC gene of an Acinetobacter baumannii isolate showing co-resistance to carbapenems and colistin. Isolate 52971 showed low ceftazidime MIC values due to the disruption of bla_ADC-195 by this insertion sequence. The introduction of an intact bla_ADC in isolate 52971 increased ceftazidime MIC. The potential of insertion sequences to inactivate chromosome-encoded resistance determinants should be explored.

SUBMITTER: Nodari CS 

PROVIDER: S-EPMC12691676 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature