Dual transcriptomic profiling of <i>Staphylococcus aureus</i> endocarditis in a porcine model reveals strong parallels with human infection.

ABSTRACT: Understanding the intricate interactions between Staphylococcus aureus and valve cells during the course of endocarditis is crucial for developing more effective treatments for an infection that has a mortality rate exceeding 30%. To investigate the molecular adaptations occurring in both the valve tissue and bacteria during infection, we performed dual RNA-seq analysis on valves from patients undergoing valve replacement surgery due to S. aureus endocarditis as well as from an experimental pig model of the disease. The results revealed remarkably consistent expression profiles between human and pig samples, characterized by endothelial damage and the activation of valve interstitial cells, leading to excessive inflammation, heightened coagulation cascades, collagen degradati

SUBMITTER: Garcia B 

PROVIDER: S-EPMC12691691 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature