<i>Bacillus velezensis</i> LoaP promotes antitermination by antagonizing NusA.

ABSTRACT: The transcription factor NusG is essential for the bacterial transcription elongation complex (TEC). During elongation, NusG dynamically interacts with other proteins, affecting transcription-translation coupling, processivity, and termination. NusG is integral to antitermination complexes, where it associates with other factors to modify the TEC, allowing it to bypass termination sites. In Gammaproteobacteria, these complexes enhance the expression of ribosomal RNA operons, bacteriophage operons, and CRISPR arrays. Specialized NusG paralogs, such as LoaP, RfaH, and UpxY, are believed to form their own unique antitermination complexes. RfaH, the only well-studied paralog, binds to a paused TEC via a specific nontemplate DNA sequence. The RfaH-bound TEC then enhances transcription-translati

SUBMITTER: Jermain MD 

PROVIDER: S-EPMC12691694 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature