Vitamin E and Fatty Acid Intake and Cardiometabolic Multimorbidity Risk: The Mediating Role of Plasma Lipid Metabolites.

ABSTRACT: Cardiometabolic multimorbidity (CMM), defined as the co-occurrence of two or more of the following: diabetes, ischemic heart disease, stroke, and other cardiovascular diseases, is a leading cause of global mortality. Although vitamins and fatty acid are known to influence cardiometabolic diseases through lipid metabolism, the mediating role of lipid metabolites in linking dietary vitamins and fatty acid intake to CMM remains unclear. We conducted a case-control study based on the Ningxia cohort, including 200 patients with CMM and 200 age- and sex-matched controls. Dietary intake was assessed using a semi-quantitative food frequency questionnaire, and plasma lipid profiles were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry. We assessed associations between

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12691755 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature