Association Between Pneumoconiosis and Pleural Empyema: A Retrospective Cohort Study.

ABSTRACT: Background: Pneumoconiosis is associated with chronic pulmonary and systemic complications, yet its relationship with pleural empyema remains insufficiently defined. This study evaluated the risk of pleural empyema among individuals with pneumoconiosis using a nationwide population-based cohort. Methods: Using Taiwan's National Health Insurance database, we identified 14,441 patients with newly diagnosed pneumoconiosis and 57,764 matched controls by age, sex, and index year. Pleural empyema was ascertained using ICD-based definitions. Cox proportional hazards models, stratified and cluster-adjusted to account for matched design, were used to estimate hazard ratios (HRs). Competing-risk models, propensity score matching, E-value estimation, and mediation analysis were performe

SUBMITTER: Soh KS 

PROVIDER: S-EPMC12691826 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature