Structural Characterization and Immunomodulatory Activity of a Novel Mannoglucogalactan from <i>Tremella aurantialba</i>: Implications for Natural Immunotherapy.

ABSTRACT: Heteropolysaccharides, the principal bioactive constituents of the esteemed medicinal food Tremella aurantialba, remain poorly understood in both structure and function. Herein, we describe a novel heteropolysaccharide, designated TAP-2a, isolated from the fruiting bodies of T. aurantialba via multi-step column chromatography. With a molecular weight of 16.95 kDa, TAP-2a is dominated by the pyranose forms of ᴅ-galactose (ᴅ-Galp), ᴅ-glucose (ᴅ-Glcp) and ᴅ-mannose (ᴅ-Manp), accompanied by minor proportions of ᴅ-xylose (ᴅ-Xylp), ʟ-fucose (ʟ-Fucp) and glucuronic acid. Methylation-GC-MS and exhaustive 1D/2D NMR analyses revealed a backbone assembled from →6)-α-Galp-(1→, →6)-β-Glcp-(1→, and →3)-α-Manp-(1→residues, branched at

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12691847 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature