Gene Polymorphisms Determining Sex Hormone-Binding Globulin Levels and Endometriosis Risk.

ABSTRACT: Endometriosis is a hormone-dependent disease, in the pathophysiology of which sex hormones (androgens, estrogens, etc.) are involved. The level of bioactive androgens/estrogens (in the free state) in the organism largely depends on sex hormone-binding globulin (SHBG), which binds/transports a significant portion of the androgens/estrogens of the body and, due to this, changes the amount of these hormones in a free state (bioactive), which may be important in the development of endometriosis. The study was devoted to identifying the link between the genetic determinants (single nucleotide polymorphisms [SNPs]) of SHBG (according to predating genome-wide associative studies [GWAS]) and the risk of endometriosis in the Caucasian women of Russia. The study was accomplished on a total sample of

SUBMITTER: Ponomareva T 

PROVIDER: S-EPMC12691900 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature