A Comparative Metabolomics Study of Multiple Urological Diseases by Highly Sensitive Dansylation Isotope Labeling LC-MS.

ABSTRACT: Urine analysis is a straightforward, non-invasive testing method that, when integrated with metabolomics, shows great potential for detecting small-molecule metabolites as biomarkers of abnormal metabolic activity in the urinary tract, including drug interactions, toxicity, and diseases. However, integrated and comparative analyses of multiple urinary tract pathologies are currently limited. In this study, ¹²C2/¹³C2-chemical dansylation labeling was used to explore the urinary amine/phenol-metabolome profiles of eight urological conditions compared with normal profiles. We obtained ten samples for each condition (disease and normal) from a total of 90 participants, pooling them as representative samples, and constructed metabolite panels to differentiate various urolo

SUBMITTER: Wang WH 

PROVIDER: S-EPMC12691989 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature