Multi-Target Screening of Anti-Diabetic and Antioxidant Potential Bioactive Constituents from Dandelion.

ABSTRACT: Taraxacum mongolicum Hand.-Mazz (TMHM), a primary source of dandelion, is a globally recognized edible and medicinal plant with significant potential in food, medicine, daily chemical products, and animal husbandry. Although hypoglycemic effects have been reported in other Taraxacum species, the specific hypoglycemic constituents and mechanisms of TMHM are not well understood. The absence of comprehensive multi-target screening methodologies has hindered the elucidation of TMHM's dual inhibitory effects on α-amylase and α-glucosidase, as well as its associated molecular mechanisms. In this study, a multi-target screening strategy was developed to concurrently evaluate α-amylase and α-glucosidase inhibition, integrating multi-target affinity ultrafiltration coupled with ultra-

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC12692036 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature