Resilience of the Skin Microbiome in Atopic Dermatitis During Short-Term Topical Treatment.

ABSTRACT: Atopic dermatitis (AD) is associated with microbial dysbiosis and impaired skin barrier function. Topical therapies, such as moisturisers and antimicrobial fragrance compounds, may modulate the skin microbiome and support disease management. The objective was to evaluate how a moisturiser and a fragrance compound (farnesol) influence skin microbiome composition in individuals with AD and healthy controls. In a randomised, controlled, operator-blinded study, 15 AD patients and 15 healthy controls applied a moisturiser, farnesol, moisturiser + farnesol, or no treatment to defined skin areas over 7 days. Microbiome composition, alpha/beta diversity, and core taxa were analysed using shotgun metagenomics. At baseline, AD patients exhibited distinct microbial profiles, including elevated Sta

SUBMITTER: Ahlstrom MG 

PROVIDER: S-EPMC12692048 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature