Interactions Between Tryptase-Positive Mast Cells and Melanin-A⁺ Cells in the Microenvironment of Cutaneous Melanoma.

ABSTRACT: Cutaneous melanoma remains one of the most aggressive tumors, yet the role innate immunity plays in its progression remains poorly understood. Effector elements with high regulatory potential, capable of both promoting and inhibiting tumor growth-mast cells (MCs), are of particular interest. This includes quantitatively characterizing the interactions between tryptase-positive mast cells (MCs) with atypical Melanin-A⁺ cells and describing their spatial phenotype, in relation to the stage of cutaneous melanoma. A retrospective analysis was carried out on samples retrieved from 128 patients with cutaneous melanoma (AJCC 8th edition: IA-IIID). Histological analysis, histochemistry (toluidine blue, Giemsa), and diplex /multiplex IHC for tryptase and Melan-A were performed; as well a

SUBMITTER: Atiakshin D 

PROVIDER: S-EPMC12692133 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature