Ethanolic Extract of Kinkeliba (<i>Combretum micranthum</i>), Rich in Phenolic Compounds Mitigates DSS-Induced Ulcerative Colitis in C57BL/6 Mice via Antioxidation and Microbiota Regulation.

ABSTRACT: Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are chronic inflammatory disorders of the gastrointestinal tract, and current therapies are limited by adverse side effects. Combretum micranthum G. Don (kinkeliba), a medicinal plant traditionally used in West Africa, has been reported to possess pharmacological activities and a favorable safety profile. In this study, an ethanolic extract of Combretum micranthum (EECM) was characterized using HPLC-DAD-ESI-MS to identify its phenolic constituents. Acute colitis was induced in C57BL/6 mice using 3% DSS, while EECM (100 and 200 mg/kg) was administered orally for seven days. Disease Activity Index was monitored daily, and colonic injuries were evaluated through macroscopic and histological ana

SUBMITTER: Sall IM 

PROVIDER: S-EPMC12692256 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature