CCN2/CTGF-Driven Myocardial Fibrosis and NT-proBNP Synergy as Predictors of Mortality in Maintenance Hemodialysis.

ABSTRACT: Chronic inter-dialytic volume overload and uremic inflammation activate TGF-β/Smad3 and p38 MAPK pathways, inducing connective tissue growth factors (CCN2/CTGF)-mediated fibrosis and NT-proBNP secretion from over-stretched cardiomyocytes. The combined rise in CTGF and NT-proBNP reflects myocardial fibrosis, stiffness and remodeling, predicting cardiovascular (CV) death in maintenance hemodialysis (MHD) patients. From molecular pathology to clinical translation, circulating CCN2/CTGF and NT-proBNP levels and bio-clinical data among MHD patients were measured in this prospective cohort. Multivariate Cox regression analysis identified independent predictors of mortality, which were incorporated into a composite risk-score model. The predictive performance for all-cause, CV, and sudden cardiac

SUBMITTER: Ko WC 

PROVIDER: S-EPMC12692257 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature