Mitigating Mucoadhesion of β-Cyclodextrins via PEGylation: Insights from ¹⁹F Diffusion NMR Analysis.

ABSTRACT: β-Cyclodextrin (β-CD)-based materials are widely used in drug delivery, yet their interactions with mucosal barriers remain insufficiently understood. Because the mucus layer coating epithelial surfaces can hinder drug transport, elucidating β-CD-mucin interactions is critical for optimizing cyclodextrin-based carriers. In this study, we examined whether PEGylation can attenuate the mucoadhesive behavior of β-CD. Monomethoxy poly(ethylene glycol)-modified β-CDs (MPEG-β-CDs) were evaluated using ¹⁹F self-diffusion NMR spectroscopy coupled with a kinetic diffusion model describing reversible binding to stationary substrates. Mucin hydrogels were prepared from bovine submaxillary mucin and served as a model mucus environment. Diffusion coefficients were extracted from the ^19</

SUBMITTER: Nguyen KTH 

PROVIDER: S-EPMC12692281 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature