Thirty-Day Mortality Associated With Carbapenemase-Producing <i>Enterobacterales</i> Bloodstream Infections at a Referral Hospital in Peru, 2020-2023.

ABSTRACT:

Background

Bloodstream infections (BSIs) caused by carbapenemase-producing Enterobacterales (CPE) are associated with increased mortality rates. However, limited data exist in Latin America, particularly in regions where bla _NDM is predominant.

Methods

We conducted a retrospective cohort study of adult inpatients with Escherichia coli or Klebsiella pneumoniae BSI at a Peruvian referral hospital between 2020 and 2023. Patients were classified as CPE or non-CPE based on molecular testing. The outcome was 30-day all-cause mortality. Multivariable Cox regression was used to identify independent predictors of mortality, adjusting for confounders selected via a directed acyclic graph.

Results

Among 506 patients, 97 (19.2%) had CPE BSIs

SUBMITTER: Perez-Lazo G 

PROVIDER: S-EPMC12692351 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature