Interkingdom Biofilms Are Affected by Non-Antibiotic Strategies: In Vitro Study in Lubbock Chronic Wound Biofilm Model.

ABSTRACT: Chronic wound infections associated with resistant polymicrobial biofilms are often refractory to conventional therapies with sustained healing time. This study evaluated the efficacy of non-antibiotic treatments including Methylglyoxal-MGO-Light-Emitting Diode-LED-and Complex Magnetic Fields-CMFs-alone/combined against the biofilms of two polymicrobial mixes (MIX 1, MIX 2) containing S. aureus, P. aeruginosa and C. albicans using the Lubbock chronic wound biofilm model. At 24 h after treatment, the effects were evaluated by (i) CFU/mg reduction, (ii) Confocal Laser Scanning Microscopy-CLSM-and (iii) Scanning Electron Microscopy-SEM. All treatments significantly reduced biofilms in terms of CFU/mg in both mixes versus the controls, 24 h after treatment. MGO showed rema

SUBMITTER: Di Fermo P 

PROVIDER: S-EPMC12692427 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature