Piperine and Tabersonine, but Not Lupinine, Inhibit <i>S. proteamaculans</i> Invasion of M-HeLa Cells.

ABSTRACT: The pathogenesis of a bacterial infection is a multistep process typically involving bacterial attachment to the host, toxin production, and/or invasion, followed by inflammation. For many bacteria, the invasion of human cells is a key step in the spread of infection and evasion of host immunity. Fusion of host cell membranes during bacterial penetration is a necessary step in invasion. The aim of this study was to evaluate the plant alkaloids, such as piperine, tabersonine, and lupinine, which have the potential to inhibit membrane fusion, fighting bacterial infection. Despite previous data on lupinine's inhibition of membrane fusion, it has no effect on invasion or on the synthesis of the proinflammatory cytokines. This was likely due to the synthesis of the surface protein OmpX, which w

SUBMITTER: Bozhokina E 

PROVIDER: S-EPMC12692479 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature