Salivary Oxidative Stress Biomarkers in Peri-Implant Disease: A Systematic Review and Meta-Analysis.

ABSTRACT: Peri-implantitis, a common biological complication of dental implants, is characterized by soft-tissue inflammation and progressive bone loss. Oxidative stress is increasingly implicated in its pathogenesis, yet the diagnostic potential of salivary redox biomarkers remains unclear. This study's objective was to assess the association between salivary malondialdehyde (MDA) and total antioxidant capacity (TAC) and peri-implant disease via a pre-registered, quantitative meta-analysis of previously published studies using predefined statistical criteria. Following a priori PROSPERO registration, we systematically searched PubMed, Scopus, and Web of Science (2004-September 2025), extracted data in duplicate, and pooled effects using random-effects models; certainty of evidence was appraised wit

SUBMITTER: Popa PS 

PROVIDER: S-EPMC12692554 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature