Epithelial-Mesenchymal Transition Increases the Susceptibility of Human A549 Cells to Nanosecond Pulsed Electric Fields.

ABSTRACT: Nanosecond pulsed electric fields (nsPEFs) are ultrashort, high-intensity electrical pulses that have unique biological actions, including the formation of membrane nanopores and the efficient induction of cell death. nsPEFs are currently regarded as a promising modality for cancer therapy. During cancer progression, abnormal cells become more malignant through epithelial-mesenchymal transition (EMT). EMT is a biological process in which cells acquire mesenchymal traits and thereby increase their motility and invasiveness. Despite the importance of EMT in cancer progression, however, limited information is available on whether EMT modulates cellular responses to nsPEFs. In this study, we compared the responses of EMT and non-EMT human A549 cells to nsPEFs. We found that EMT induction rende

SUBMITTER: Mitsui M 

PROVIDER: S-EPMC12692578 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature