Mapping Interactions Between Cytokines, Chemokines, Growth Factors, and Conventional Biomarkers in COVID-19 ICU-Patients.

ABSTRACT: Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyperinflammation with cytokine and chemokine release, alongside elevations in conventional laboratory biomarkers such as C-reactive protein (CRP), ferritin, and procalcitonin (PCT). However, the interplay between cytokines, chemokines, growth factors (CCGFs), and standard biomarkers remains incompletely understood. Therefore, we aimed to evaluate associations between CCGFs and conventional biomarkers from a broad aspect, utilizing the prospective PronMed cohort of critically ill COVID-19 patients admitted to the intensive care unit (ICU) at Uppsala University Hospital. Plasma concentrations of 92 CCGFs were analyzed in each patient using the Olink Target 96 Cardiovascular II panel and analyzed in relation to conventio

SUBMITTER: Eriksson MB 

PROVIDER: S-EPMC12692695 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature