TRIM47 inhibits murine norovirus replication in a strain-dependent manner.

ABSTRACT: Human norovirus is the leading cause of gastroenteritis worldwide. Norovirus exhibits remarkable genetic diversity. Understanding the impact of genetic diversity on infection and immunity has been challenging due to the difficulties in in vitro cultivation and the current lack of a small animal model. Murine norovirus (MNV) has emerged as a premier model system to investigate norovirus biology. Here, we identify TRIM47 as a host restriction factor that potently inhibits MNV infection in a strain-dependent manner. We determine that TRIM47 expression inhibits an early stage of the viral life cycle of the MNV strain CR6 (MNV^CR6), while the replication of the closely related strain CW3 (MNV^CW3) is not restricted by TRIM47. MNV^CW3 causes an acute infectio

SUBMITTER: Crockett SL 

PROVIDER: S-EPMC12692738 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature