Design and Synthesis of Structurally Modified Analogs of 24<i>Z</i>-Isomasticadienonic Acid with Enhanced Anti-Proliferative Activity.

ABSTRACT: Τriterpenic acids represent a prominent class of bioactive compounds, with a wide range of biological properties, including anti-inflammatory, antiviral, and anticancer effects. Among them, 24Z-isomasticadienonic acid (IMNA), a major constituent of Chios Mastic Gum, has attracted little attention compared with other well-studied triterpenes such as oleanolic or betulinic acid, largely because its isolation in sufficient purity and quantity was only recently achieved. In this study, a series of IMNA analogs was synthesized through targeted modifications at the A-ring. These included the introduction of heteroatoms at position 2, the incorporation of heterocyclic rings such as an oxazole and a thiazole, and rearrangements of the ring structure. The new compounds were evaluated for the

SUBMITTER: Stamou P 

PROVIDER: S-EPMC12692795 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature