Synthetic Biomaterials for Alveolar Bone Regeneration: A Systematic Review of Clinical Evidence.

ABSTRACT:

Background

Alveolar bone resorption remains a major challenge in implant and prosthetic rehabilitation. While autologous bone grafts are still considered the gold standard, their biological and surgical limitations have promoted the use of synthetic biomaterials such as biphasic calcium phosphate (BCP), β-tricalcium phosphate (β-TCP), nanocrystalline hydroxyapatite, and bioactive glass.

Methods

This systematic review, conducted in accordance with PRISMA guidelines, was based on a comprehensive search performed in March 2025 across PubMed, MEDLINE, Embase, and Google Scholar. A total of 11 clinical studies-including both randomized and non-randomized comparative trials-were identified. Due to the marked heterogeneity of study designs and outcome measures, meta-analysis was no

SUBMITTER: Bozza B 

PROVIDER: S-EPMC12692858 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature