Dual Regulation of Corneodesmosome Formation by Shotokuseki Extract Enhances Skin Barrier Homeostasis.

ABSTRACT: Corneodesmosomes are specialized intercellular junctions that mediate adhesion between corneocytes in the stratum corneum (SC). The degradation of these structures is regulated by kallikrein-related peptidases (KLKs) and their inhibitors. This study aimed to elucidate the effects of Shotokuseki extract (SE), a substance rich in various trace elements, on molecules related to SC adhesion using a three-dimensional cultured human epidermis model. SE was applied to a three-dimensional epidermis model, and analyses were conducted on gene expression, protease activity, protein levels, and tissue structure. SE treatment significantly upregulated the mRNA expression of corneodesmosomal components (desmoglein1, desmocollin1, and corneodesmosin) and the major protease inhibitor serine peptidase inhi

SUBMITTER: Tsukui K 

PROVIDER: S-EPMC12693148 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature