Tetrametallic Au@Ag-Pd-Pt Nanozyme with Surface-Exposed Active Sites for Enhanced Catalytic Activity.

ABSTRACT: Metal nanoparticles (NPs) with enzyme-mimicking activities, known as nanozymes, are being actively explored for biomedical and analytical applications. Enhancing their catalytic activity and metal utilization efficiency is crucial for advancing these technologies. Here, we report an aqueous-phase, room-temperature synthesis of tetra-metallic Au@Ag-Pd-Pt NPs that exhibit superior peroxidase-like activity compared to their mono-, bi-, and trimetallic counterparts. The synthesis involves a sequential, seed-mediated approach comprising the formation of Au NP seeds, the overgrowth of a Ag shell, and the galvanic replacement of Ag with Pd and Pt ions. We systematically investigated the effects of the Au core diameter (15, 40, 55 nm), Ag precursor concentration (50-400 µM), and the Pd-to-Pt ratio

SUBMITTER: Panferov VG 

PROVIDER: S-EPMC12693165 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature