Supramolecular Photosensitizers Based on HMeQ[6] and Their Photodynamic Effects on Triple-Negative Breast Cancer Cells.

ABSTRACT: The principal challenge in the development of efficient porphyrin-based photosensitizers is the intrinsic aggregation-induced quenching effect, which significantly impairs the generation efficiency of singlet oxygen (¹O₂) in photodynamic therapy (PDT). This study addresses this limitation through a supramolecular approach grounded in host-guest chemistry. Partially methyl-substituted cucurbit[6]uril (HMeQ[6]) was selected as the macrocyclic host owing to its smaller portal size and larger outer diameter, features that facilitate both strong binding affinity and effective spatial isolation. A porphyrin derivative functionalized with two cationic arms (DPPY) was designed and synthesized as the guest molecule. The results derived from ¹H NMR titration and UV s

SUBMITTER: Song B 

PROVIDER: S-EPMC12693310 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature