Relationship Between Mast Cell Population of Microenvironment and Prognosis in Colorectal Cancer.

ABSTRACT: Background: Mast cells are integral components of the tumor microenvironment and have been implicated in the regulation of tumor progression in various malignancies. The association between inflammation and colorectal cancer (CRC) development has become increasingly recognized. Depending on the tumor microenvironment, mast cells may exert either pro-tumorigenic or antitumorigenic functions. Objective: This study aimed to evaluate the relationship between stromal mast cell density and prognostic factors in patients with CRC. Methods: In this retrospective cohort study, 81 patients who underwent curative surgical resection for CRC were analyzed. Immunohistochemical staining for mast cell tryptase (MCT) was performed on paraffin-embedded tumor specimens. Mast cells were q

SUBMITTER: Yeldir N 

PROVIDER: S-EPMC12693393 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature