Mesenchymal stem cells alleviate pulmonary fibrosis and gut microbiota dysbiosis in systemic sclerosis.

ABSTRACT:

Introduction

Mesenchymal stem cells (MSCs) have shown the potential to alleviate systemic sclerosis (SSc) tissue fibrosis. However, our knowledge of the effects of MSCs on gut microbiota remains limited.

Methods

In this study, we employed a bleomycin induced SSc model to investigate the effects of MSCs on pulmonary fibrosis and gut microbiota in SSc using transcriptomic, microbial metagenomic, and metabolomic analyses.

Results

Our results indicated that MSCs treatment alleviated lung injury in SSc mice. Transcriptomic analysis suggested that the therapeutic effects of MSCs were primarily associated with fatty acid metabolism, PPAR signaling pathway, and AMPK signaling pathway. Furthermore, MSCs restored the relative abundance of microbial taxa, including Bacteroido

SUBMITTER: Ni B 

PROVIDER: S-EPMC12693401 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature