Biliary Reconstruction in Liver Transplantation with Primary Sclerosing Cholangitis: Roux-en-Y Hepaticojejunostomy or Duct-to-Duct Anastomosis?

ABSTRACT: Background/Objectives: Biliary reconstruction in liver transplantation (LT) for primary sclerosing cholangitis (PSC) is controversial. A Roux-en-Y hepaticojejunostomy (HJ) is associated with fewer anastomotic strictures, while a duct-to-duct reconstruction (DD) shows a decreased rate of cholangitis and preserves anatomy for endoscopy. The aim of our study was to analyze patient survival and postoperative outcomes after LT for PSC based on the type of reconstruction in two high-volume LT centers. Methods: We included 94 PSC patients who underwent a primary LT between 2010 and 2024. The association of biliary reconstruction with patient survival was assessed with the Kaplan-Meier method. Predictors of mortality and postoperative complications were identified via Cox and logisti

SUBMITTER: Dancs PT 

PROVIDER: S-EPMC12693685 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature