Point-of-Care Testing in PKU: A New ERA of Blood Phenylalanine Monitoring.

ABSTRACT: Background: In phenylketonuria (PKU) patients, dried blood spot (DBS) sampling remains the standard method for monitoring phenylalanine (Phe) levels. However, delays in reporting results can hinder timely dietary adjustments. Patients and caregivers have expressed a preference for point-of-care testing (POCT) devices that enable home-based monitoring. Objectives: Our aim was to compare blood Phe measurements in PKU patients and caregiver usability of a POCT system with DBS, which is the standard practice monitoring method. Methods: Twenty participants (eighteen children with PKU and two healthy controls) were recruited. Caregivers of children with PKU were asked to perform blood Phe measurements at home under the supervision of a researcher, using both the POCT device

SUBMITTER: Pinto A 

PROVIDER: S-EPMC12693881 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature