Dual-Modality Ultrasound Imaging of SPIONs Distribution via Combined Magnetomotive and Passive Cavitation Imaging.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPIONs) have shown promise across a wide range of biomedical applications, including targeted drug delivery, magnetic hyperthermia, magnetic resonance imaging, and regenerative medicine. In the context of local tumor therapy (Magnetic Drug Targeting, MDT) SPIONs can be functionalized with chemotherapeutic agents and accumulated at tumor sites using an externally applied magnetic field. To achieve effective drug accumulation and therapeutic efficacy, precise positioning of the accumulation magnet relative to the tumor is essential. To address this need, we propose a dual-modality ultrasound imaging approach combining magnetomotive ultrasound (MMUS) and passive cavitation mapping (PCM). MMUS detects magnetically induced displacements to localize SP

SUBMITTER: Huber CM 

PROVIDER: S-EPMC12693940 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature