Dynamic brain mechanisms supporting salient memories under cortisol.

ABSTRACT: Cortisol is known to promote memory for emotionally arousing experiences, yet the neural networks involved in enhancing these memories are unknown. Here, we combine pharmacological fMRI with an analysis approach to determine the dynamic brain network processes by which cortisol enhances the formation of emotional memories. We introduce dynamic connectome-based predictive modeling (dCPM) to identify high temporal resolution, whole-brain functional connectivity networks, and show that distinct networks can successfully predict trial-level arousal (involving salience network) and subsequent memory (involving visual, frontoparietal, and default mode networks). We find that, under cortisol, brain networks associated with both processing arousal and forming memories have more structural and func

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12693973 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature