Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin.

ABSTRACT: Emerging evidence demonstrates that self-reactive CD8⁺ T resident memory cells (T_RM cells) may already populate the never-lesional (NL) skin of patients with chronic inflammatory conditions, including vitiligo. However, their functional activity and regulation remain unknown. By combining cellular and transcriptomic approaches, we show that common CD8⁺ T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional (PL) skin of patients with vitiligo. Pathways related to immune activation were more active in T cells from PL skin, while those related to immune regulation were enriched in NL skin T cells, also evidenced by the stronger infiltration of regulatory T cells and the higher expression of programmed cell death protein 1 (PD-1)

SUBMITTER: Migayron L 

PROVIDER: S-EPMC12693980 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature